The Biochemistry of Detoxification – Cellular Cleansing and Mitochondrial Renewal
By Gabriel Nicolaev – CyGuru | Founder of Medicinas & Nicolaev Medicine
Introduction
For more than fifteen years I have watched people recover simply by allowing their bodies to clean themselves. Detoxification is not a fashion—it is cell biology. When the internal terrain is pure, every enzyme, mitochondrion, and DNA strand works with precision. When it is polluted, even the strongest medicine struggles. Modern research confirms what natural healers have always known: healing begins with biochemical and energetic purification (Nieman & Wentz, J. Nutr. Biochem., 2019).
The Cellular Logic of Detox
Every second, hepatic enzymes transform thousands of xenobiotics, heavy metals, and metabolic residues. This process unfolds in three phases:
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Phase I – Activation.
Cytochrome P450 enzymes oxidize or reduce lipophilic toxins into reactive intermediates. These radicals are necessary but dangerous; they must be neutralized quickly. -
Phase II – Conjugation.
Here the liver uses glutathione, sulfur, glycine, and methyl donors to bind the intermediates. Antioxidants such as vitamins C and E regenerate the glutathione cycle (Klaassen & Watkins, Pharmacol. Rev., 2021). -
Phase III – Elimination.
Transporters expel conjugates through bile, urine, sweat, and breath. Adequate hydration and fiber finalize the excretion.
When any of these steps slows, the organism stores toxins in fat, bone, and connective tissue. The result is chronic inflammation, mitochondrial fatigue, and premature aging.
Mitochondria: The Engines of Renewal
Detoxification is meaningless without mitochondrial recovery. These organelles not only create ATP but also sense redox balance through NAD⁺/NADH and reactive oxygen species (ROS). Excess ROS damage membranes and DNA, leading to cellular senescence (López-Otín et al., Cell, 2023).
Natural compounds—coenzyme Q10, alpha-lipoic acid, and polyphenols—restore electron flow and stimulate mitochondrial biogenesis via PGC-1α signaling (Scarpulla, Biochim. Biophys. Acta, 2011).
Heavy-Metal Chelation and Binding
Industrial pollution leaves traces of mercury, lead, and cadmium in the body. These metals interfere with enzymes and displace essential minerals like zinc and selenium.
Among the safest chelators is modified citrus pectin—the active ingredient in my formula Tumopectin.
Studies show it binds galectin-3 and heavy metals without affecting vital elements (Eliaz et al., Pharmacological Research, 2019). By lowering galectin-3, Tumopectin also decreases fibrosis and metastatic potential, proving that detox can be both biochemical and anti-cancerous.
Nutrient Synergy in Medicinas Detox Formulas
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Imune 369 combines Spirulina platensis, Chlorella vulgaris, marine calcium, selenium-enriched yeast, basil, and ginseng.
These ingredients supply chlorophyll, magnesium, and antioxidant enzymes (SOD, CAT) that enhance hepatic Phase II conjugation and rebuild mineral reserves depleted by toxins. -
Casinovita C provides high-absorption vitamin C supporting glutathione regeneration. It neutralizes ROS formed during Phase I and protects mitochondrial membranes from lipid peroxidation.
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CardioVeg, rich in hawthorn, garlic, and coenzyme Q10, detoxifies the vascular system by reducing LDL oxidation and improving endothelial nitric-oxide signaling. Clean vessels mean efficient oxygen delivery to detoxifying tissues.
Together these formulas act as a multi-organ purification system: Imune 369 cleans the terrain, Tumopectin captures the waste, CardioVeg restores circulation, and Casinovita C re-energizes the mitochondria.
The Role of the Microbiome
Detox pathways depend heavily on gut bacteria. Certain strains of Lactobacillus and Bifidobacterium convert plant fibers into short-chain fatty acids (SCFAs) such as butyrate, which maintain intestinal barrier integrity (Parada Venegas et al., Front. Immunol., 2019).
Without this barrier, endotoxins enter the bloodstream—a condition known as metabolic endotoxemia.
Imune 369’s chlorella and basil powders feed these beneficial microbes, sustaining what I call the inner filter.
Oxidative Stress and Redox Signaling
Detox is not the eradication of ROS but their intelligent modulation.
Low levels of ROS act as signaling molecules for adaptation; high levels create damage.
Casinovita C and the polyphenols in CardioVeg fine-tune this redox dance, ensuring that oxidation leads to regeneration, not destruction.
When this balance is achieved, mitochondria emit coherent infrared photons—a measurable signature of cellular vitality (Popp, Biophysical Research Communications, 1979).
The Energy Perspective – CyGuru Interpretation
On the energetic plane, detoxification is the clearing of stagnant frequencies.
Each toxin carries a chaotic vibration that distorts the electromagnetic harmony of the organism.
When biochemical waste leaves, so do the low-frequency emotions attached to it—fear, anger, guilt.
In frequency terms, the liver resonates near 315 Hz, associated with courage and action. When overloaded, its vibration drops, leading to fatigue and indecision.
Through herbs like ginseng and basil, Imune 369 raises this vibration; through modified pectin, Tumopectin removes dense energies from the cellular matrix.
Casinovita C adds photons of purity, while CardioVeg opens the heart field to coherent circulation of light.
“Detox is the alchemy of turning darkness into current.”
— Gabriel Nicolaev – CyGuru
Protocol of Application
I guide patients to approach detox in three synchronized layers:
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Physical:
Imune 369 – 6 capsules/day before meals.
Tumopectin – 5 capsules/day in three doses.
CardioVeg – 2 capsules after lunch and dinner.
Casinovita C – 1000 mg morning and evening. -
Lifestyle:
Hydration > 2 L/day, sleep 7 hours, sweating through cardio or sauna, and grounding barefoot daily. -
Energetic:
Sound frequency 528 Hz for cellular repair, breathing 4-7-8 rhythm, gratitude meditation morning and night.
Within three weeks, biomarkers such as ALT, CRP, and oxidative stress indicators (MDA) typically normalize—a reflection of restored internal coherence.
Conclusion
Detoxification is the intersection of biochemistry, microbiology, and bio-energy.
It is not an external cleansing but an awakening of the body’s own intelligence to remove what no longer resonates with life.
Through Medicinas formulas—Imune 369, Tumopectin, CardioVeg, and Casinovita C—we integrate nature’s molecules with vibrational precision, guiding cells back to clarity and light.
When the mitochondria shine, consciousness expands.
And in that light, healing becomes not a miracle, but a measurable consequence of harmony.
